Collagen from salted jellyfish (Rhopilema esculentum): Structural characterization, emulsifying properties and wound healing potential
Hu, Bing, Zong, Zixin, Han, Lingyu, Yao, Ziang, Yang, Jixin, Liu, Ronggang, Cao, Jijuan and Al-Assaf, Saphwan (2026) Collagen from salted jellyfish (Rhopilema esculentum): Structural characterization, emulsifying properties and wound healing potential. Gels, 12 (7). ISSN 2310-2861
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Abstract
Jellyfish collagen, a sustainable and biocompatible marine biomaterial, holds great potential in food and biomedical applications. This study explores the emulsification properties and therapeutic potential of pepsin-soluble collagen derived from salt-preserved Rhopilema esculentum (RPSC). Structural analysis confirmed that RPSC retained an intact triple-helix structure with a denaturation temperature of approximately 36.0 °C and formed elastic gels at concentrations ≥1.5% (w/w). As an emulsion stabilizer, RPSC (2%, w/w) effectively stabilized oil-in-water emulsions with oil fractions up to 50%, forming viscoelastic networks that exhibited excellent centrifugal stability but limited freeze–thaw tolerance. The gel–sol transition occurred near 38.0 °C, consistent with the thermal denaturation of RPSC. As a wound healing promoter, RPSC showed no cytotoxicity and dose-dependently enhanced 3T3 fibroblast viability, migration, and SOD activity. Notably, RPSC downregulated TGF-β1 expression and suppressed endogenous type I collagen synthesis, indicating a scar-mitigating profile distinct from conventional pro-fibrotic collagen dressings. These findings establish RPSC as a bifunctional marine biomaterial for both emulsified food systems and regenerative wound dressings in the biomedical field.
| Item Type: | Article |
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| Keywords: | Rhopilema esculentum, emulsion stability, rheological property, wound healing, marine biomaterial |
| Divisions: | Applied Science, Computing and Engineering |
| Depositing User: | Hayley Dennis |
| Date Deposited: | 16 Jul 2026 10:55 |
| Last Modified: | 16 Jul 2026 10:55 |
| URI: | https://wrexham.repository.guildhe.ac.uk/id/eprint/18472 |
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