Hydrophobic derivatization of sodium alginate for use in fucoxanthin delivery
Han, Lingyu, Zhai, Ruiyi, Williams, Peter A, Hu, Bing, Yang, Jixin, Dong, Nuo, Ban, Yujie and Li, Tingting (2025) Hydrophobic derivatization of sodium alginate for use in fucoxanthin delivery. Food Hydrocolloids, 170 (111664). ISSN 0268-005X
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Abstract
The present study successfully devised an innovative pH-sensitive system for encapsulating fucoxanthin, which effectively shielded RAW 264.7 cells from H2O2-induced damage. The formulation requires modification of sodium alginate with octanoyl chloride (C8) via esterification to provide amphiphilic self-assembly capacity of the system and loading of fucoxanthin via sonication. The hydration diameter (193.9–167.9 nm) and critical aggregation concentration of the micellar-like aggregates (1.4–0.5 mg/mL) gradually decreased with the increasing degree of substitution (1.54 %–60.20 %). The encapsulation efficiency (46.11 %–88.54 %) and loading capacity (4.61 %–8.85 %) showed a positive correlation with the increasing degree of substitution. The TEM confirmed complete fucoxanthin encapsulation in micellar-like aggregates, forming smooth-surfaced spherical particles. In vitro simulated digestion assays demonstrated that micellar-like aggregates effectively shielded fucoxanthin from premature gastric release, while significantly improving its release efficiency during the intestinal phase. Fucoxanthin-loaded micellar-like aggregates endocytosed by RAW 264.7 cells alleviated cellular oxidative stress damage by reducing ROS levels. The study demonstrates the potential of self-assembled sodium alginate nanoparticles as a novel carrier for efficient delivery of hydrophobic substances, thereby establishing an innovative formulation for alleviating oxidative stress.
| Item Type: | Article |
|---|---|
| Keywords: | Sodium alginate, hydrophobic modification, fucoxanthin, encapsulation |
| Divisions: | Applied Science, Computing and Engineering |
| Depositing User: | Hayley Dennis |
| Date Deposited: | 18 Aug 2025 05:01 |
| Last Modified: | 18 Aug 2025 05:01 |
| URI: | https://wrexham.repository.guildhe.ac.uk/id/eprint/18327 |
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